DESCRIPTION:Eisen et al. 1995: The SNF2 family of proteins includes representatives from a variety of species with roles in cellular processes such as transcriptional regulation (e.g. MOT1, SNF2 and BRM), maintenance of chromosome stability during mitosis (e.g. lodestar) and various aspects of processing of DNA damage, including nucleotide excision repair (e.g. RAD16 and ERCC6), recombinational pathways (e.g. RAD54) and post-replication daughter strand gap repair (e.g. RAD5). This family also includes many proteins with no known function. To better characterize this family of proteins we have used molecular phylogenetic techniques to infer evolutionary relationships among the family members. We have divided the SNF2 family into multiple subfamilies, each of which represents what we propose to be a functionally and evolutionarily distinct group. We have then used the subfamily structure to predict the functions of some of the uncharacterized proteins in the SNF2 family. We discuss possible implications of this evolutionary analysis on the general properties and evolution of the SNF2 family.
Members of this family
SHOULD possess SNF2_N domain
SHOULD NOT possess AP2 PHD domains
References
Bork, P; Koonin, EV. 1993. An expanding family of helicases within the 'DEAD/H' superfamily. Nucleic Acids Res. 21(3):751-2 PUBMEDID:8382805
Eisen, JA; Sweder, KS; Hanawalt, PC. 1995. Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions. Nucleic Acids Res. 23(14):2715-23 PUBMEDID:7651832