DESCRIPTION:Doerks et al. 2001: Homology-based sequence analyses have revealed the presence of a novel domain (DDT) in bromodomain PHD finger transcription factors (BPTFs), chromatin remodeling factors of the BAZ-family and other putative nuclear proteins. This domain is characterized by a number of conserved aromatic and charged residues and is predicted to consist of three alpha helices. Recent studies indicate a likely DNA-binding function for the DDT domain.
Members of this family
SHOULD possess DDT domain
SHOULD NOT possess Alfin-like Homeobox domains
References
Doerks, T; Copley, R; Bork, P. 2001. DDT -- a novel domain in different transcription and chromosome remodeling factors. Trends Biochem. Sci. 26(3):145-6 PUBMEDID:11246006