DESCRIPTION:Hofmann & Bucher 1995: The typical FHA domain comprises approximately 55-75 amino acids and contains three highly conserved blocks separated by more divergent spacer regions.
From PFAMThe domain
is present in a diverse range of proteins, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins and metabolic enzymes which partake
in many different cellular processes - DNA repair, signal transduction, vesicular transport and protein degradation are just a few examples.
Members of this family
SHOULD possess FHA domain
References
Durocher, D; Jackson, SP. 2002. The FHA domain. FEBS Lett. 513(1):58-66 PUBMEDID:11911881
Hofmann, K; Bucher, P. 1995. The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors. Trends Biochem. Sci. 20(9):347-9 PUBMEDID:7482699